Research Paper Volume 14, Issue 20 pp 8205—8220
Age-associated changes in microglia activation and Sirtuin-1- chromatin binding patterns
Figure 4. Transcription of mir-142-5p and Sirt1 genes in PFC from young animals and animals that lived to age. The expression of these genes was measured by qRT-PCR in total PFC extracted mRNA and normalized against GAPDH. Relative values of (A) mir142-5p and (B) Sirt1 were compared between young (4-7 yo), shorter-lived (18-20yo) and longer-lived (23 – 29 yo) elder groups. *p<0.05 in Bonferroni’s multiple comparisons.