Research Paper Volume 14, Issue 20 pp 8302—8320

Figure 4. Tanshinone IIA (TIIA) preserved renal mitochondrial function in renal ischemia-reperfusion (IR)-induced renal injury. The MMP (ratio of red/green), the opening of mPTP (%), the mitochondrial ROS, the mtDNA damage (ratio of long/short fragments), the mitochondrial RCR, mitochondrial oxygen consumption rate (A), the mitochondrial respiratory chain complex enzymes (I, II, III, IV, and V), and ATP (B) were recorded above. Electron microscope pictures (10 000×, 40 000×) of renal tissue after IR, the scale bars represents a length of 2 μm and 200 nm on tissues respectively. Abnormal mitochondrial (paired yellow arrow) morphology show that mitochondrial membrane rupture or swellings, normal mitochondrial (single yellow arrow) morphology type show that mitochondrial membrane smooth and inner carinulae distinct (C), and percentage of damaged mitochondria (C). Data are shown as mean ± SD. *p < 0.05 versus sham group, ^#p < 0.05 versus IR (obese) group, ^∆p < 0.05 versus TIIA (5 mg/kg.d) group, ^F070p < 0.05 versus TIIA (10 mg/kg.d) group. (n=3).