Figure 7.Diagram of the mechanism by which SFN prevents Ang II-induced cardiomyocyte apoptosis. Ang II activates oxidative stress by increasing ROS leading to inflammation, oxidative stress and fibrosis in cardiomyocytes. SFN prevent Ang II-induced cardiomyocyte apoptosis by inhibiting HDACs to activate Nrf2 and downstream antioxidant genes.
