MicroRNA-148a induces apoptosis and prevents angiogenesis with bevacizumab in colon cancer through direct inhibition of ROCK1/c-Met via HIF-1α under hypoxia

Hsiang-Lin Tsai; Yueh-Chiao Tsai; Yen-Cheng Chen; Ching-Wen Huang; Po-Jung Chen; Ching-Chun Li; Wei-Chih Su; Tsung-Kun Chang; Yung-Sung Yeh; Tzu-Chieh Yin; Jaw-Yuan Wang

doi:doi:10.18632/aging.204243

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Research Paper Volume 14, Issue 16 pp 6668—6688

MicroRNA-148a induces apoptosis and prevents angiogenesis with bevacizumab in colon cancer through direct inhibition of ROCK1/c-Met via HIF-1α under hypoxia

Figure 9. Relationship between therapeutic response and serum miR-148a expression in mCRC patients. We collected the serum samples of 24 mCRC patients before they received treatment with bevacizumab plus FOLFIRI as first-line regimen. (A) After treatment, 14 patients showed partial response (PR) and 10 patients had progressive disease (PD). (B) miR-148a expression was significantly higher in the serum samples of the 14 PR patients than in those of the 10 PD patients (P = 0.026).