Research Paper Volume 14, Issue 14 pp 5641—5668

Figure 3. PCBrainAge acceleration is associated with indications of AD. (A) PCBrainAge residuals following multiple correction were verified to remain orthogonal to age using a scatterplot with LOESS curves for males (green) and females (purple). PCBrainAge Acceleration was subsequently analyzed in the context of CERAD scores (B), Braak stages (C), NIA Reagan scores (D), the ante-mortem clinical diagnosis (E), and the APOE ε4 carrier status (F) of each individual. P-values are the result of performing Kruskal-Wallis tests of nonparametric means amongst the categorical groups. Error bars for 3B-3F depict 1 standard error. (G) Acceleration was further broken down into cognitive groups by APOE ε4 carrier status for improved clarity. Error bars depict the 95% confidence interval. Significance levels based on BH adjusted p values are: ^*P < 0.05, ^**P < 0.01; ^***P < 0.001.