The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: evidence from network pharmacology, molecular docking and experimental validation

Xiaojun Chen; Jiangyan Wang; Lin Tang; Qiuying Ye; Qunwei Dong; Zhangwei Li; Li Hu; Chenghong Ma; Jiake Xu; Ping Sun

doi:doi:10.18632/aging.204172

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Research Paper Volume 14, Issue 14 pp 5727—5748

The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: evidence from network pharmacology, molecular docking and experimental validation

Figure 6. Top 5 docking modes between compounds and enriched genes of the TNF pathway are shown as 3D and 2D diagrams. (A) The binding modes of Coptisine to Ptgs2. (B) The binding modes of Coptisine to Pik3cb. (C) The interaction modes of Magnoflorine with Ptgs2. (D) The binding modes of Coptisine to Mmp9. (E) The interaction modes of 13-Methylberberine with Ptgs2.