Research Paper Volume 14, Issue 13 pp 5345—5365

Figure 6. (A, B) Grip strength, (C) mechanical allodynia, and (D) thermal hyperalgesia and (B’ and D’) simple linear regression for circulating and central steroid hormones among young adult and middle-aged HIV-1 Tat-transgenic male mice [Tat(+)] or their non-Tat-expressing age-matched counterparts [Tat(−)]. Grip strength threshold for (A) forelimbs alone or (B) forelimbs and hindlimbs together. (C) Paw-withdrawal threshold (g) in an electronic Von Frey test. (D) Paw-withdrawal latency (s) in a thermal probe test. Simple linear regressions between (B’) circulating corticosterone and forelimbs and hindlimbs together or (D’) hippocampal allopregnanolone and paw-withdrawal latency. ^*main effect for Tat(+) mice to differ from Tat(−) mice. ^†main effect for middle-aged mice to differ from young adults. ^{^}significant interaction wherein indicated group differs from young adult Tat(−) controls. Regression lines (solid) are depicted with 95% confidence intervals (dotted), (two-way ANOVA, p ≤ 0.05).