Figure 2.Effect of overexpression and downregulation of CRT overexpression on cell apoptosis in HCC cells treated with HDAC inhibitors. (A, B) shRNA-mediated knockdown of CRT enhances drug-resistance in HDAC inhibitor-treated cells than in HA22T parental cells. (C–F) Overexpression of CRT overexpression enhances HDAC inhibitor-induced chemosensitivity in HDAC inhibitor-resistant cells than in parental cells. All protein samples are analyzed using western blotting. Protein expression is normalized to expression of GAPDH. *p <0.05, **p <0.01, ***p<0.001 compared with control group.
