Research Paper Volume 14, Issue 10 pp 4556—4571
The impact of ALDH7A1 variants in oral cancer development and prognosis
Figure 1. The validated results of ALDH7A1 expression by Genotype-Tissue Expression (GTEx) Portal (https://www.gtexportal.org/home/). (A–C) In GTEx, which enrolled 54 non-diseased tissue sites across nearly 1000 individuals, violin plots of ALDH7A1 rs13182402 mutation was associated with higher ALDH7A1 expression level in upper aerodigestive (esophagus) mucosa, whole blood, and musculoskeletal system than those of ALDH7A1 allele normal type (P < 0.001, < 0.001, < 0.001, respectively). (D) ALDH7A1 mRNA expression in cancer tissue of 30 oral cancer patients was analyzed by quantitative real time-PCR assay.