Research Paper Volume 14, Issue 10 pp 4247—4269

Figure 4. Effect of Humanin G (HNG) on IL-1β, IL-13, and IL-17A proteins. IL-1β protein was elevated in AMD plasma (A) and in AMD RPE cybrid cells (B) compared to their normal counterparts. Treatment with HNG reduced IL-1β protein levels in AMD RPE cybrid ells (C) but not in normal RPE cybrid cells (D), compared to their untreated counterparts. IL-13 protein was elevated in AMD plasma (E) and in AMD RPE cybrid cells (F) compared to their normal counterparts. Treatment with HNG reduced IL-13 protein levels in AMD RPE cybrid ells (G) but not in normal RPE cybrid cells (H), compared to their untreated counterparts. IL-17A protein was elevated in AMD plasma (I) and in AMD RPE cybrid cells (J) compared to their normal counterparts. Treatment with HNG reduced IL-17A protein levels in AMD RPE cybrid ells (K) but not in normal RPE cybrid cells (L), compared to their untreated counterparts. Data are presented as mean ± SEM. * P<0.05; ** P<0.01; ns: non-significant.