Research Paper Volume 14, Issue 10 pp 4247—4269

Figure 2. Effect of Humanin G (HNG) on CD62E/E-Selectin, CD62P/P-Selectin, and ICAM-1 proteins. CD62E/E-Selectin protein was increased significantly in AMD plasma (A) and in AMD RPE cybrid cells (B) compared to their normal counterparts. Treatment with HNG reduced CD62E/E-Selectin protein levels in AMD RPE cybrid ells (C) but not in normal RPE cybrid cells (D), compared to their untreated counterparts. CD62P/P-Selectin protein was elevated in AMD plasma (E) and in AMD RPE cybrid cells (F) compared to their normal counterparts. Treatment with HNG reduced CD62P/P-Selectin protein levels in AMD RPE cybrid ells (G) but not in normal RPE cybrid cells (H), compared to their untreated counterparts. ICAM-1 protein was elevated in AMD plasma (I) and in AMD RPE cybrid cells (J) compared to their normal counterparts. Treatment with HNG reduced ICAM-1 protein levels in AMD RPE cybrid ells (K) but not in normal RPE cybrid cells (L), compared to their untreated counterparts. Data are presented as mean ± SEM. * P<0.05; ** P<0.01; ns: non-significant.