Figure 6 — Claudin-5 relieves cognitive decline in Alzheimer’s disease mice through suppression of inhibitory GABAergic neurotransmission

Research Paper|Volume 14, Issue 8|pp. 3554–3568

Claudin-5 relieves cognitive decline in Alzheimer’s disease mice through suppression of inhibitory GABAergic neurotransmission

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Figure 6.Claudin-5 modulated GABAergic transmission to mediate synaptic plasticity. (A–C) Effects of claudin-5 knockout on sIPSCs frequency and amplitude (n = 9 per group; two-tailed Student’s t-test). Scale bars: 20 pA, 2 s. (D, E) HFS-evoked IPSCs during HFS in hippocampal CA1 neurons in claudin-5^+/− mice and their control littermates (n = 9 cells from 4 mice; two-tailed Student’s t-test). Scale bars: 200 pA, 1 s. (F, G) The GABA_A receptor antagonist BMI blocked impaired effects of claudin-5 knockout on LTP (n = 6; two-tailed Student’s t-test). Data show mean ± s.e.m. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.