Research Paper Volume 14, Issue 5 pp 2304—2319
Downregulation of ZC3H13 by miR-362-3p/miR-425-5p is associated with a poor prognosis and adverse outcomes in hepatocellular carcinoma
Figure 3. Mir-362-3p/mir-425-5p downregulates ZC3H13 in liver cancer. (A) The miRNA-ZC3H13 regulatory network established by Cytoscape software. (B) ZC3H13 is negatively correlated with miR-362-3p in LIHC analyzed by the starBase database. (C) Mir-362-3p is overexpressed in LIHC analyzed by UALCAN. (D) The prognostic value of miR-362-3p in HCC assessed by Kaplan–Meier plotter. (E) ZC3H13 is negatively correlated with miR-425-5p in LIHC analyzed by the starBase database. (F) Mir-425-5p is overexpressed in LIHC analyzed by UALCAN. (G) The prognostic value of miR-425-5p in HCC assessed by Kaplan–Meier plotter. (H, I) MiR-362-3p/miR-425-5p mimic and inhibitor results detected by qPCR. (J) MiR-362-3p/miR-425-5p mimic and inhibitor results detected by western blot. **P<0.01.