Review Volume 14, Issue 3 pp 1562—1588
The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure
Figure 3. Icariin reverses ageing-induced deficits in the brain of ageing models. Icariin not only prolongs life span of ageing animals but also improves cognitive function and motor coordination by promoting neurogenesis, enhancing neuronal autophagy, increasing sirtuins protein like Sirt1, Sirt3, Sirt6, and exerting antioxidant effect in the brain.