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Research Paper Volume 14, Issue 3 pp 1292—1306

Effect of visfatin on KATP channel upregulation in colonic smooth muscle cells in diabetic colon dysmotility

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Figure 4. The expression of KATP channels were altered in T2DM rats. (A) Immunohistochemical staining of Kir6.1 and SUR2B subunits of KATP channels in the colon muscle layers in the two groups of rats at 18 w. Left panel: Representative image; right panel: Quantitative analysis. Low magnification, 200×, scale bar = 100 μm; high magnification, 400×, scale bar = 50 μm. (B) Western blotting analysis of Kir6.1 and SUR2B subunits of KATP channels in the colon muscle layers in the two groups of rats at 18 w. Relative expression was normalized to that of GAPDH. Left panel: Representative image; right panel: Quantitative analysis. *P < 0.05, **P < 0.01, control group n = 10, T2DM group n = 8.