Figure 8 — Huangqi Guizhi Wuwu Decoction can prevent and treat oxaliplatin-induced neuropathic pain by TNFα/IL-1β/IL-6/MAPK/NF-kB pathway

Research Paper|Volume 14, Issue 12|pp. 5013–5022

Huangqi Guizhi Wuwu Decoction can prevent and treat oxaliplatin-induced neuropathic pain by TNFα/IL-1β/IL-6/MAPK/NF-kB pathway

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Figure 8.The effect of Huangqi Guizhi Wuwu Decoction on the expression of ERK1/2, p38, JNK, c-Fos, CREB and NF-kB in the L4-L5 dorsal root ganglions of different rat groups detected by IHC. (A–F) The typical pictures of ERK1/2, p38, JNK, c-Fos, CREB and NF-kB expression in the L4-L5 dorsal root ganglions of different rat groups detected by IHC. (G) The average optical density of ERK1/2, p38, JNK, c-Fos, CREB, and NF-kB expression in the L4-L5 dorsal root ganglions of different rat groups.