Priority Research Paper Volume 13, Issue 21 pp 23876—23894

Figure 2. Altered mitochondrial morphology and activity in tau^wt-expressing larvae. Wild type and tau^wt L1 (A) and L4 (B) larvae body bends per 30 seconds in M9 buffer. (C) Mitochondrial population in the ventral nerve cord of L1 nematodes. (D) Representative fluorescent images of transgenic nematodes expressing pan-neuronally mitochondria-targeted mKate2::HA. Scale bar, 20 μm. Tau^wt-expressing L1 larvae display (E) smaller, (F, G) more circular and (H) Fewer active mitochondria compared to wild type animals. Scale bar, 100 μm. (n = 50; NS P > 0.05, ^**P < 0.001, ^***P < 0.0001; unpaired t-test).