Research Paper Volume 13, Issue 19 pp 23376—23392
Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis
Figure 8. Overexpression of KLF12 promoted LUAD progression. (A) Three groups were transfected using miR-188-5p mimics, miR-188-5p mimics+KLF12 ov, and NC mimics in the A549 cell line. The cell proliferative capacity of the three groups was measured using the (B) CCK-8 (p < 0.05), (C) BrdU (*p < 0.05), and (D) colony formation (p < 0.01) assays. (E) Overexpression of KLF12 resulted in a significant reduction in the apoptosis ratio (upper right quadrant+lower right quadrant). The transwell chamber results indicated that overexpression of KLF12 significantly promoted cell (F) migration (p < 0.01) and (G) invasion (p < 0.01), which were suppressed by miR-188-5p.