Identification of hub genes and key pathways of paraquat-induced human embryonic pulmonary fibrosis by bioinformatics analysis and <i>in vitro</i> studies

Xiangxia Zeng; Jinlun Hu; Mei Yan; Chunming Xie; Weigan Xu; Qiaohua Hu; Jinxia Feng; Zi Cong Gu; Yue Fu

doi:doi:10.18632/aging.203570

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Research Paper Volume 13, Issue 19 pp 22792—22801

Identification of hub genes and key pathways of paraquat-induced human embryonic pulmonary fibrosis by bioinformatics analysis and in vitro studies

Figure 5. Module analysis of the PPI network. Up-regulated genes are marked in light red, down-regulated genes are marked in light blue (A). The most significant module generated from the PPI network. JUNB, FOSL2, SOCS3, DUSP1, CCL2, CEBPD, CXCL2, ATF3 protein–protein interaction (B). Up-regulated genes are marked in light red, down-regulated genes are marked in light blue.