Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome

Hisaya Kato; Yoshiro Maezawa; Naoya Takayama; Yasuo Ouchi; Hiyori Kaneko; Daisuke Kinoshita; Aki Takada-Watanabe; Motohiko Oshima; Masaya Koshizaka; Hideyuki Ogata; Yoshitaka Kubota; Nobuyuki Mitsukawa; Koji Eto; Atsushi Iwama; Koutaro Yokote

doi:doi:10.18632/aging.202696

← Back

Research Paper Volume 13, Issue 4 pp 4946—4961

Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome

Figure 2. Transcriptome analysis showed distinct gene expression profiles between the trunk and foot fibroblasts. (A) Heatmap of differentially expressed genes between the trunk and foot. Cutoff: |log2(Foot/Trunk)| > 1 and FDR < 0.05. (B) List of the top seven Gene Ontology (GO: biological process) terms and corresponding p values related to Figure 2A. (C) Differentially expressed genes specifically involved in embryonic development and mesenchymal cell differentiation. Data are means ± SEM of two patients (technically n=2 in each sample).