Research Paper Volume 13, Issue 4 pp 5718—5747
Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer
Figure 10. Correlation between the level of FANCE expression and immune infiltration in HNSC obtained from the TIMER database (https://cistrome.shinyapps.io/timer/). (A) FANCE expression was significantly negatively correlated with infiltration of CD4+ T cells, macrophages, neutrophils, and dendritic cells in HNSC. Tumor purity and FANCE were found to have a significant positive correlation, while B cell and CD8 + T cell infiltration levels and FANCE expression were not significantly correlated. (B, C) Similar negative correlations were observed with the level of infiltrating lymphocytes in HPV-negative HNSC samples, but no significant correlation was found in HPV-positive patients.