Figure 3.Immunometabolism-Mediated therapies targeting T-cell dysfunction in COVID-19. Onset of cytokine storm as treatment opportunity via rapamycin, metformin, and dimethyl fumarate. Inhibition of mTOR by rapamycin, AMPK by metformin and Nrf2 activation by dimethyl fumarate may restore CD8+ T-cell functionality and improve antiviral response and patient outcome.
