Research Paper Volume 12, Issue 24 pp 25916—25938

Figure 7. Predicted transcription factors (TFs) of HNRNPA2B1 and HNRNPC in EMs. (A) Predicted Gene-TF network of HNRNPA2B1 and HNRNPC in the training dataset. (Grey circles, unshared differentially expressed TFs between the EU vs. NM matrix and the EC vs. EU matrix; Red circles, TFs upregulated both in the EU vs. NM matrix and EC vs. EU matrix (p < 0.05); Green circles, TFs downregulated both in the EU vs. NM matrix and EC vs. EU matrix (p < 0.05); Blue circles, TFs with contrary expression trend in the EU vs. NM matrix and EC vs. EU matrix (p < 0.05). (B, D) The expression of ESR1 and NFYA in training (‘Kruskal.test’) and validation (‘DEseq2’ package) datasets in EMs. (C, E) The expression of HNRNPA2B1 and HNRNPC positively correlated with ESR1 and NFYA in training and validation datasets in EMs. EMs, endometriosis; NM, normal endometrium; EU, eutopic endometrium; EC, ectopic endometrium. * p < 0.05; ** p < 0.01; *** p < 0.001.