Different doses of ovalbumin exposure on dendritic cells determine their genetic/epigenetic regulation and T cell differentiation

Ying Wang; Zizhong Yu; Yue Zhou; Yun Zhu; Jinhui Wang; Junmei Fu; Yang Yuan; Shan Chen; Yanjun Wang; Wenting Yu; Pei Gao; Wanting Zhu; Qing Cheng; Seong H Cho; Weijia Kong; Jianjun Chen

doi:doi:10.18632/aging.104145

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Research Paper Volume 12, Issue 24 pp 25432—25451

Different doses of ovalbumin exposure on dendritic cells determine their genetic/epigenetic regulation and T cell differentiation

Figure 5. Intergroup analysis of 10000-0 DCs. (A) Volcano diagram shows the genes that are expressed in the difference. (B) Distribution of DMR in different regions of the genome. (C) Enrichment analysis of up-expressed genes. (D) Enrichment analysis of down-expressed genes. (E, F). DMR overlapping gene pathway enrichment analysis, the results are shown by the scatter diagram. (E). Gene body area. (F). Promoter area (transcriptional initiation site upstream 2kb). (G). Screening for genes with significant negative correlation between RNA-seq differential gene expression and average gene methylation level. Significant negative correlation gene-protein Interaction Network Map. n = 3 independent experiments.