Research Paper Volume 12, Issue 16 pp 15995—16020

Figure 6. Autophagic markers in the brain of 3xTg-AD mice. Beclin-1 and LC3 II expression in brain homogenates of 3xTg-AD mice (panel A). GAPDH was used as a control to check equal protein loading (^*p<0.05, ^**p<0.01 and ^***p<0.001 vs T0, ^###p<0.001 vs C, ^§§p<0.01 and ^§§§p<0.001 vs LAB). Cathepsin L and B activity measured in brain homogenates of 3xTg-AD mice, T0, C, LAB and p62-LAB groups (panel B) (^**p<0.01 and ^***p<0.001 vs T0, ^##p<0.01 and ^###p<0.001 vs C, ^§§p<0.01 vs LAB).