Figure 3.Graphene oxide (GO) inhibited metastasis in Hela cells. (A) The wound closure and wound healing rate of Hela cells treated with different doses of GO at 0, 6, 12 h and 24 h by wound healing assay. (B) Cell migration and migration rates in Hela cells treated with different doses of GO by Transwell assay. (C) Expression of metastasis-related proteins, including matrix metalloproteinase 2 (MMP2), MMP3, MMP9, intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), collagen type I (Col-1), Col-3, Racl, Rho and Cdc42, by western blotting. *P < 0.05, and **P < 0.01 vs control cells.
