Research Paper Volume 12, Issue 17 pp 17528—17540

Figure 2. Tc2 facilitated the secretion of cytokines, especially anti-inflammatory factors, compared with Tc1. (A) Naïve CD8⁺ T cells (CD44⁻CD25⁻CD62L^high) from the spleens of WT mice and Tc1 and Tc2 from 7-day UUO kidneys were isolated and cultured for 24 h (2 × 10⁵ cells per well). The culture medium was collected for the detection of inflammatory factors by using a Luminex multiplex murine cytokine assay. (B–D) Proinflammatory cytokines, anti-inflammatory cytokines, and chemokines in the cell culture medium that were significantly changed are shown (*p < 0.05 vs. naïve CD8⁺ T cells, #p < 0.05 vs. Tc1).