Research Paper Volume 12, Issue 16 pp 16172—16182
Leptin promotes bone metastasis of breast cancer by activating the SDF-1/CXCR4 axis
Figure 5. High CXCR4 expression promoted bone metastasis of breast cancer. (A) IHC staining was employed to examine CXCR4 expression in breast cancer tissues. (B) Integrated optical density (IOD) analysis indicated that Leptin receptor and CXCR4 expression were positively correlated in breast cancer patients. Pearson’s correlation analysis was used to determine the correlation coefficient (r) and p value. (C) Frequencies of bone metastasis and non-bone metastasis in patients with low or high CXCR4 expression.