Research Paper Volume 12, Issue 12 pp 12187—12205

Figure 6. Parallel analysis of the effect of B7-H3, CD47 and CD8 on survival of HCC patients in the SYSUCC cohort. (A) Representative images of high and low expression of CD8, B7-H3 and CD47 detected by IHC in HCC tissues (Magnifications: 200× and 400x [the left-lower corner in the images]). (B) Survival curves of HCC patients stratified by combined expressions of B7-H3 and CD8 proteins: the survival of patients with B7-H3^low/CD8^high is significantly better than that of those with B7-H3^high/CD8^high (P = 0.043), B7-H3^highCD8^low (P = 0.003) or B7-H3^low/CD8^low (P = 0.048) and no significance between other groups. (C) Survival curves of HCC patients stratified by combined expression of CD47 and CD8 proteins: the survival of patients with CD47^high/CD8^low is significantly worse than that of those with CD47^high/CD8^high (P = 0.01), CD47^lowCD8^high (P < 0.001) or CD47^low/CD8^low (P = 0.003) and no significance between other groups. H represents high and L represents low respectively (log rank test).