Priority Research Paper Volume 12, Issue 11 pp 10041—10058

Figure 5. Decreased Ldh expression in adult brain extended lifespan. Survival curves of males with reduced Ldh expression via Ldh^RNAi combined with tim^ts (A, D), elav^ts (B, E), or repo^ts (C, F) and their controls at 27°C and 25°C, respectively. Ldh decrease significantly extends lifespan compared to controls (pairwise comparison by Gehan-Breslow-Wilcoxon test yielded p<0.0001 for all graphs except p<0.05 for repo^ts> Ldh^RNAi versus control at 25°C). See Supporting Information Supplementary Table 3 for experimental details.