First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

Béla Ózsvári; Federica Sotgia; Michael P. Lisanti

doi:doi:10.18632/aging.103336

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Research Paper Volume 12, Issue 11 pp 10162—10179

First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

Figure 9. Effects of Dodecyl-TPP on tumor growth. Dodecyl-TPP, another more potent mitochondrially-targeted TPP compound, was tested using low micro-molar concentrations (6.25- and 25-μM). Note that Dodecyl-TPP significantly inhibited tumor growth (by 12% to 40%). Averages are shown + SEM. *p<0.05; ***p<0.001. The structure of Dodecyl-TPP (d-TPP) is also shown. Note the 12-carbon alkyl-chain attached to the lipophilic cation, triphenyl-phosphonium (TPP).