Figure 2 — First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

Research Paper|Volume 12, Issue 11|pp. 10162–10179

First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

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Figure 2.A CSC-based mitochondrial 13-gene signature predicts distant metastasis in ER(+) breast cancer patients. We used 13 gene transcripts to create a CSC-based mitochondrial-related gene signature, that effectively predicted distant metastasis in N=1,395 patients (HR=1.79; P=3.4e-07). See also Supplementary Table 1.