First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

Béla Ózsvári; Federica Sotgia; Michael P. Lisanti

doi:doi:10.18632/aging.103336

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Research Paper Volume 12, Issue 11 pp 10162—10179

First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

Figure 2. A CSC-based mitochondrial 13-gene signature predicts distant metastasis in ER(+) breast cancer patients. We used 13 gene transcripts to create a CSC-based mitochondrial-related gene signature, that effectively predicted distant metastasis in N=1,395 patients (HR=1.79; P=3.4e-07). See also Supplementary Table 1.