ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L

Haiyan Liu; Dan Guo; Yuou Sha; Chenlu Zhang; Yijing Jiang; Lemin Hong; Jie Zhang; Yuwen Jiang; Ling Lu; Hongming Huang

doi:doi:10.18632/aging.103326

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Research Paper Volume 12, Issue 11 pp 11100—11115

ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L

Figure 11. CDC5L interference inhibits the CAM-DR promotion effect of ANXA7. (A) The levels of CD44, ICAM1 and VCAM1 in U266 co-cultured with BMSC after transfection were detected by ELISA assay. *P<0.05, **P<0.01 and ***P<0.001 vs.U266 group. ^###P<0.001 vs. U266+BMSC group. ^ΔΔΔP<0.001 vs. U266+BMSC+ OE-ANXA7 group. (B) The apoptosis of U266 cells treated with bortezomib in co-culture system was determined by TUNEL assay.