Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases

Jon Danel Solano-Iturri; Maider Beitia; Peio Errarte; Julio Calvete-Candenas; María C. Etxezarraga; Alberto Loizate; Enrique Echevarria; Iker Badiola; Gorka Larrinaga

doi:doi:10.18632/aging.103261

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Research Paper Volume 12, Issue 11 pp 10337—10358

Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases

Figure 5. Soluble FAP (sFAP) plasmatic levels in AdC patients (n=127) and in healthy subjects (n=50). (A) sFAP levels were significantly lower in AdC patients than in controls (T Student, p<0.0001). (B) sFAP levels below 30,11 ng/mL were significantly associated with worse overall survival of AdC patients (Log-rank test, p=0.001).