Research Paper Volume 12, Issue 11 pp 10300—10316

Figure 5. The glycolytic and cholesterogenic gene profiles of other cancer types. (A) Heat map depicting that glycolytic and cholesterogenic genes were robustly co-expressed when consensus clusters were applied to each individual cancer type. (B) Top: Bar plots showing the proportions of the metabolic subgroups across the various cancer types. Bottom: The correlation between cholesterogenic gene expression and the expression of Hoshida poor prognostic genes, KRAS, MYC and MPC1/2 in each cancer type. Median glycolytic gene expression correlated positively (BH-adjusted p < 0.05) with basal-like gene expression in all cancer types. The correlation between MPC1/2 expression and glycolytic gene expression was validated using Wilcoxon rank sum tests and BH correction. (C) Kaplan-Meier survival analysis curves depicting the differences in median overall survival across the metabolic subgroups in CESC. (D) Kaplan-Meier survival analysis curves demonstrating the differences in median overall survival in KIRC.