Figure 8 — Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone

Research Paper|Volume 12, Issue 10|pp. 9761–9780

Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone

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Figure 8.ANCOVA shows that GH-deficiency decreases VO₂ and VCO₂. Overall averaged VO₂ (A–D) and VCO₂ (E–H) values are plotted on the y-axis and body weights are plotted on the x-axis. Relationship between body weight and VO₂ in female (A, C) and male (B, D) WT and GHRH^-/- mice during light cycle (A, B) and dark cycle. (C, D) Relationship between body weight and VCO₂ in female (E, G) and male (F, H) WT and GHRH^-/- mice in light cycles (E, F) and dark cycles. (G, H) Female WT n=12, GHRH^-/- n=12, male WT n=12, GHRH^-/- n=11. The WT and GHRH^-/- groups were statistically analyzed with ANCOVA method, which was used to calculate p values, shown on each panel.