microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy <i>via</i> ISL1-mediated sonic hedgehog signaling pathway

Qin Sun; Jun Zeng; Yang Liu; JingYan Chen; Qing-Cui Zeng; Yan-Qiu Chen; Li-Li Tu; Ping Chen; Fan Yang; Min Zhang

doi:doi:10.18632/aging.103230

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Research Paper Volume 12, Issue 12 pp 11446—11465

microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway

Figure 3. miR-9 and miR-29a reduce peripheral nerve conduction velocity and nociception threshold in rats with DM. (A) The paw withdrawal latency and paw withdrawal threshold of normal rats and rats with DM following lentiviral infection. (B) The nerve conduction velocity of normal rats and rats with DM following lentiviral infection on the 28^th day after model development; * p < 0.05 vs. the normal group; # p < 0.05 vs. the DM group; @ p < 0.05 vs. the LV-ISL1 + LV-miR-9 group; & p < 0.05 vs. the LV-ISL1 + LV-miR-29a group. Results were measurement data and expressed as mean ± standard deviation; the repeated measures analysis of variance was used to analyze data at different time points; n = 8; the experiment was repeated three times independently.