Integrated data analysis reveals significant associations of <i>KEAP1</i> mutations with DNA methylation alterations in lung adenocarcinomas

Mohamed Elshaer; Ahmed Islam ElManawy; Ahmed Hammad; Akhileshwar Namani; Xiu Jun Wang; Xiuwen Tang

doi:doi:10.18632/aging.103068

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Research Paper Volume 12, Issue 8 pp 7183—7206

Integrated data analysis reveals significant associations of KEAP1 mutations with DNA methylation alterations in lung adenocarcinomas

Figure 6. Differential gene expression analysis. (A) Volcano plot showing the distribution of DEGs between KEAP1-mutated and wild-type LUAD patient samples based on significance and fold change. (B) Pie chart showing the percentages of overexpressed and underexpressed genes. (C) Heatmap showing the top DEGs between KEAP1-mutated and wild-type LUAD patient samples with Log Fc>|2| and p <0.05.