Figure 3. Function Retention Index (FRI) and Function Acquisition Index (FAI) for each of TSIX, BEST1, ADAMTSL4 and MAP3K13. FRI reflects the ratio of the functions in the NOR group that were retained in the FRA group (FRI=common functions in both groups/all functions in FRA group). FAI reflects the ratio of the novel functions in the FRA group that were absent from the NOR group (FAI=new functions in FRA group/all functions in FRA group).