Figure 1. Joint effect of demand-control status and APOE ɛ4 on incident dementia among adults aged ≤72 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) derived from Cox regression model adjusted for age, sex, education, heart diseases, leisure activity engagement, and early-life socioeconomic status. APOE ɛ4, apolipoprotein E ɛ4.