The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma

Bo Chen; Qiqi Zhang; Xujing Wang; Yongkun Wang; Jiaqu Cui; Huiren Zhuang; Jianying Tang

doi:doi:10.18632/aging.102835

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Research Paper Volume 12, Issue 4 pp 3647—3661

The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma

Figure 6. ENSG00000254041.1 increase the chemoresistance of PC cells to gemcitabine in vitro. (A) GSEA analysis revealed that ENSG00000254041.1 expression associated with the multi-drug resistance. (B) Knockdown of ENSG00000254041.1 decreased the IC₅₀ values of GEM in SW1990 and BxPC-3 cells, and overexpression of ENSG00000254041.1 in Panc-1 cells increased the IC₅₀ values of GEM. ***p < 0.001 compared with indicated group.