Research Paper Volume 12, Issue 4 pp 3502—3515

Figure 1. Representation of the biological relationships between healthy and unhealthy aging by subnetworks. The processes shared by 50 or more common proteins (i.e., those reflecting the strongest relationships) are shown. Nodes are filled in green and red background for proteins upregulated and downregulated, respectively, in healthy, functional centenarians compared with a control group with the opposite phenotype (i.e., mostly composed of people with low functional independence and who died from cardiovascular disease before becoming an octogenarian).