LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p

Honghai Song; Jiaming Liu; Xin Wu; Yang Zhou; Xuanyin Chen; Jiangwei Chen; Keyu Deng; Chunxia Mao; Shanhu Huang; Zhili Liu

doi:doi:10.18632/aging.102427

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Research Paper Volume 11, Issue 21 pp 9794—9810

LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p

Figure 1. LHX2 is up-regulated in osteosarcoma and predicts poor prognosis. (A) Comparison of LHX2 expression in 18 paired OS and non-tumor tissues in the GEO database. **P <0.01. (B) LHX2 mRNA levels in OS cell lines. *P <0.05, **P<0.01. (C) LHX2 protein levels in OS cell lines. LHX2 expression is relative to GAPDH. (D) IHC staining of LHX2 in OS TMA (n=40, double dots per case). (E) Statistical analysis of IHC staining in human OS TMA (n=40). (F) Distribution of LHX2 IHC staining scores in OS tissues according to distant metastasis and Enneking stage classification. (G) Kaplan-Meier survival analysis according to LHX2 expression.