Expression of Concern
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This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 11, Issue 18 pp 7678—7693
Long noncoding RNA TTN-AS1 enhances the malignant characteristics of osteosarcoma by acting as a competing endogenous RNA on microRNA-376a thereby upregulating dickkopf-1
Figure 1. TTN-AS1 is overexpressed in OS tissue samples and cell lines. (A) The expression of TTN-AS1 was analyzed in 47 pairs of OS tissue samples and adjacent normal bone tissues using RT-qPCR. *P < 0.05 vs. the normal bone tissues. (B) RT-qPCR was performed to determine TTN-AS1 expression in four OS cell lines (HOS, SAOS-2, MG-63, and U2OS) and normal osteoblasts (hFOB1.19 cells). *P < 0.05 vs. hFOB1.19 cells. (C) The Kaplan–Meier survival analysis and logrank test were applied to assess the relation between TTN-AS1 levels and the overall survival of patients with OS. The median value of TTN-AS1 expression among the OS tissue samples was chosen as a cutoff. P = 0.026.