Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain

Yaoyu Pu; Lijia Chang; Youge Qu; Siming Wang; Kai Zhang; Kenji Hashimoto

doi:doi:10.18632/aging.102221

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Research Paper Volume 11, Issue 17 pp 6915—6929

Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain

Figure 2. α-diversity and β-diversity in gut microbiota. Diversity index values for the four groups. (A) Chao 1 index (two-way ANOVA, antibiotic: F_1,36 = 15.928, P < 0.001; MPTP: F_1,36 = 37.541, P < 0.001; interaction (antibiotic × MPTP): F_1,36 = 20.587, P < 0.001). (B) ACE index (two-way ANOVA, antibiotic: F_1,36 = 12.968, P < 0.001; MPTP: F_1,36 = 43.032, P < 0.001; interaction (antibiotic × MPTP): F_1,36 = 22.827, P < 0.001). (C) Shannon index (two-way ANOVA, antibiotic: F_1,36 = 8.942, P = 0.005; MPTP: F_1,36 = 0.593, P = 0.446; interaction (antibiotic × MPTP): F_1,36 = 3.427, P = 0.072). (D) PCoA analysis of gut bacteria data (Bray–Curtis dissimilarity).