Figure 6 — Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis

Research Paper|Volume 11, Issue 9|pp. 2681–2698

Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis

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Figure 6.Mg²⁺-dependent Akt/mTOR inhibition mediates the apoptosis induction and invasion suppression effects of SLC41A1 in PDAC. (A) Mg²⁺ supplementation abrogated apoptosis induction by SLC41A1. (B) Mg²⁺supplementation abrogated the inhibition of invasion by SLC41A1. (C) Overall mechanisms underlying the anti-tumour effects of SLC41A1 in PDAC.