Figure 3 — Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis

Research Paper|Volume 11, Issue 9|pp. 2681–2698

Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis

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Figure 3.Overexpression of SLC41A1 suppresses in vitro PDAC cell proliferation and induces apoptosis. (A) Overexpression of SLC41A1 reduced the growth rate of PDAC cells KP3 and Panc-1. (B) Overexpression of SLC41A1 suppressed colony formation. (C) SLC41A1 induced the formation of apoptotic-like PDAC cells. (D) SLC41A1 suppressed the invasion of PDAC cells through the extracellular matrix. *p < 0.05; **p < 0.01; ***p < 0.001.