Figure 1. SPATA31A1 over-expression leads to reduced cell growth and increased senescence. (A) Relative number of cells per flask after each round of 3 weeks of culturing. The first round (1st Rnd) represents the normalized cell numbers three weeks after the initial seeding. Differences in normalized cell numbers became significant after the 2nd round, up to the 6th round when the experiment ended. The blue bars represent the averages and standard error of the four replicates of the control cells and the red bars the SPATA31A1 over-expressing cells. The numbers were normalized with respect to total cell counts. See