Figure 6.Schematic summary of effects of senescence, Ang II and BACE1 inhibitor IV on expression and processing of APP in human BMECs. (A) and (B) Senescence impairs α-processing of APP and enhances β-processing of APP. BACE1 inhibitor IV reverses the impairment caused by senescence by inhibiting Aβ generation and increasing expression of ADAM10 and sAPPα production. (C) and (D) Ang II impairs α-processing of APP in senescent cells. BACE1 inhibitor IV reverses reduced ADAM10 expression caused by Ang II, but does not affect sAPPα production, most likely as a result of decreased expression of APP. [↑= up-regulation, ↓=down-regulation, (-)=no effect]
