Research Paper Volume 8, Issue 10 pp 2488—2508
Dissociation between iron accumulation and ferritin upregulation in the aged substantia nigra: attenuation by dietary restriction
Figure 3. SRXRF elemental iron maps in (A) striatum, (C) globus pallidus and (E) substantia nigra with corresponding R2* maps in (B), (D) and (F) at 2, 6, 19 and 27 months. [Arrows highlight clear accumulation of iron concordant with increased R2*, most prominent between 6 and 19 months.] Qualitative increases in iron are accompanied by significant quantitative increases in iron, largely between 6 and 19 months in (G) striatum, (H) globus pallidus and I) substantia nigra. Significance level at *, P < 0.05; **, P < 0.01 and ***, P < 0.001, compared to 2 month; #, P < 0.05; ##, P < 0.01; and ###, P < 0.001, compared to 6 month, respectively.